Prop Leon Brown and full-back Jordan Williams both make their first PRO14 appearances of the season as Dragons host Zebre at Rodney Parade on Friday.
Wales international Brown and livewire number 15 Williams were absent for the game against champions Leinster but are now part of four changes made by boss Dean Ryan.
Lock Matthew Screech is called up to partner Joe Davies in the second-row for the region’s first game of the season on home soil.
Dynamic back-row Taine Basham is also named at openside flanker, with Harrison Keddie moving to blindside. Aaron Wainwright misses the game through injury.
Prop Greg Bateman could make his first appearance for Dragons after being named among the replacements.
There is also a call-up to the bench for back-row talent Ben Fry.
Meanwhile, Zebre have made three changes in personnel to their backline as they look to bounce back from last week’s opening defeat at home to Cardiff Blues.
Jacopo Trulla starts at full-back so Junior Laloifi moves out to right wing, with Federico Mori and Guglielmo Palazzani in at centre and scrum-half respectively.
There’s also tweaks made in the pack as Marco Manfredi gets the nod at hooker, Ian Nagle replaces Mick Kearney at lock while David Sisi is at number eight.
Dragons: 15 Jordan Williams, 14 Jonah Holmes, 13 Nick Tompkins, 12 Jamie Roberts, 11 Ashton Hewitt, 10 Sam Davies, 9 Rhodri Williams (c), 8 Ross Moriarty, 7 Taine Basham, 6 Harrison Keddie, 5 Matthew Screech, 4 Joe Davies, 3 Leon Brown, 2 Elliot Dee, 1 Brok Harris Replacements: 16 Richard Hibbard, 17 Greg Bateman, 18 Aaron Jarvis, 19 Joe Maksymiw, 20 Ben Fry, 21 Tavis Knoyle, 22 Josh Lewis, 23 Adam Warren
Zebre: 15 Jacopo Trulla, 14 Junior Laloifi, 13 Giulio Bisegni (c), 12 Federico Mori, 11 Mattia Bellini, 10 Carlo Canna, 9 Guglielmo Palazzani, 8 David Sisi, 7 Johan Meyer, 6 Maxime Mbandà, 5 Ian Nagle, 4 Leonard Krumov, 3 Eduardo Bello, 2 Marco Manfredi, 1 Daniele Rimpelli Replacements: 16 Massimo Ceciliani, 17 Danilo Fischetti, 18 Giosuè Zilocchi, 19 Cristian Stoian, 20 Mick Kearney, 21 Nicolò Casilio, 22 Antonio Rizzi, 23 Lorenzo Masselli
Venue: Rodney Parade Kick-off: 20:15 BST Referee: Chris Busby Assistant referees: Adam Jones, Craig Evans TMO: Sean Brickell
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